Faculty of Medicine and Health Sciences
Department of Circulation and medical imaging

Strain rate imaging.

Revised edition

References


by

Asbjørn Støylen, Professor, Dr. Med

asbjorn.stoylen@ntnu.no


This section: References for all sections

  1. Mirsky I, Parmley WW. Assessment of  Passive Elastic stiffness for isolated heart muscle and the intact heart. Circ Res 1973;33: 233-243.
  2. Andreas Heimdal. Doppler based ultrasound imaging methods for noninvasive assessment of tissue viability, NTNU 1999.
  3. H. Torp, A. Heimdal, B. Olstad, K. Kristofferson, "Method and apparatus for real-time calculation and display of strain in ultrasound imaging", U.S. patent 6099471, 2000.
  4. Asbjørn Støylen. Strain rate Imaging of the left ventricle by ultrasound. Feasibility, clinical validation and physiological aspects. NTNU 2001.
  5. Heimdal A, Stoylen A, Torp H, Skjaerpe T. Real-time strain rate imaging of the left ventricle by ultrasound. J Am Soc Echocardiogr 1998 Nov;11(11):1013-19
  6. Voigt JU, Pedrizzetti G, Lysyansky P, Marwick TH, Houle H, Baumann R, Pedri S, Ito Y, Abe Y, Metz S, Song JH, Hamilton J, Sengupta PP, Kolias TJ, d'Hooge J, Aurigemma GP, Thomas JD, Badano LP.Definitions for a common standard for 2D speckle tracking echocardiography: consensus document of the EACVI/ASE/Industry Task Force to standardize deformation imaging. J Am Soc Echocardiogr. 2015 Feb;28(2):183-93
  7. Støylen A, Mølmen HE, Dalen H. Left ventricular global strains by linear measurements in three dimensions: interrelations and relations to age, gender and body size in the HUNT Study. Open Heart 2019;6:e001050. doi:10.1136/openhrt-2019-001050
  8. Bowman AW and Kovács SJ. Left atrial conduit volume is generated by deviation from the constant-volume state of the left heart: a combined MRI-echocardiographic study. American journal of physiology Heart and circulatory physiology (2004); 286: H2416-2424.
  9. Steding-Ehrenborg K, Carlsson M, Stephensen S and Arheden H. Atrial aspiration from pulmonary and caval veins is caused by ventricular contraction and secures 70% of the total stroke volume independent of resting heart rate and heart size. Clinical physiology and functional imaging (2013); 33: 233-240.
  10. Dimond EG, Duenas A, Benchimol A. Apex cardiography. Am Heart J. 1966 Jul;72(1):124-30. doi: 10.1016/0002-8703(66)90635-1.
  11. Wandt B. Long-Axis Contraction of the Ventricles: A Modern Approach, but Described Already by Leonardo da Vinci. J Am Soc Echocardiogr 2000;13:699-706.
  12. Hamilton WF, Rompf JH. Movements of the base of the ventricle and relative constancy of the cardiac volume. Am J Physiol 1932;102:559-65.
  13. Hoffman EA, Ritman EL. Invariant total heart volume in the intact thorax. Am J Physiol 1985;249:883-90.
  14. Lundback S. Cardiac pumping and function of the ventricular septum. Acta Physiol Scand Suppl 1986;550:1-101.
  15. Carlsson M, Cain P, Holmqvist C, Stahlberg F, Lundback S, Arheden H. Total heart volume variation throughout the cardiac cycle in humans. Am J Physiol Heart Circ Physiol. 2004 Jul;287(1):H243-50.
  16. Dalen H, Thorstensen A, Vatten LJ, Aase SA, Stoylen A. Reference Values and Distribution of Conventional Echocardiographic Doppler Measures and Longitudinal Tissue Doppler Velocities in a Population Free from Cardiovascular Disease. 2010 Sep 1;3(5):614-22.
  17. Dalen H, Thorstensen A, Aase SA, Ingul CB, Torp H, Vatten LJ, Stoylen A. Segmental and global longitudinal strain and strain rate based on echocardiography of 1266 healthy individuals: the HUNT study in Norway. Eur J Echocardiogr. 2010 Mar;11(2):176-83.
  18. Støylen A, Mølmen HE, Dalen H. Relation between Mitral Annular Plane Systolic Excursion and Global longitudinal strain in normal subjects: The HUNT study. Echocardiography. 2018;35:603–610
  19. Støylen A, Mølmen HE, Dalen H. Importance of length and external diameter in left ventricular geometry. Normal values from the HUNT Study. Open Heart. 2016 Sep 21;3(2):e000465.
  20. Fleming AD, Xia X, McDicken WN, Sutherland GR, Fenn L. Myocardial velocity gradients detected by Doppler imaging.Br J Radiol. 1994 Jul;67(799):679-88.
  21. Uematsu M, Miyatake K, Tanaka N, Matsuda H, Sano A, Yamazaki N, Hirama M, Yamagishi M. Myocardial velocity gradient as a new indicator of regional left ventricular contraction: detection by a two-dimensional tissue Doppler imaging technique. J Am Coll Cardiol. 1995 Jul;26(1):217-23.
  22. Heimdal A, Stoylen A, Torp H, Skjaerpe T. Real-time strain rate imaging of the left ventricle by ultrasound. J Am Soc Echocardiogr 1998 Nov;11(11):1013-19
  23. Støylen A, Mølmen HE, Dalen H. Over all variability of mitral annular plane peak systolic velocity and peak global longitudinal strain rate in relation to age, body size, and sex: The HUNT Study. Echocardiography. 2020 Mar 10. doi: 10.1111/echo.14630. 
  24. Aurich M, Fuchs P, Müller-Hennessen M, et al. Unidimensional longitudinal strain: a simple approach for the assessment of longitudinal myocardial deformation by echocardiography. J Am Soc Echocardiogr 2018;31:733–42.
  25. Riffel JH, Andre F, Maertens M, Rost F, Keller MG, Giusca S, Seitz S, Kristen AV, Müller M, Giannitsis E, Korosoglou G, Katus HA, Buss SJ. Fast assessment of long axis strain with standard cardiovascular magnetic resonance: a validation study of a novel parameter with reference values. J Cardiovasc Magn Reson. 2015 Aug 8;17(1):69. doi: 10.1186/s12968-015-0171-8.
  26. Brodin LA, van der Linden J, Olstad B. Echocardiographic functional images based on tissue velocity information. Herz 1998, 23:1183-1199.
  27. Hor KN, Baumann R, Pedrizzetti G, Tonti G, Gottliebson WM, Taylor M, Benson DW, Mazur W. Magnetic resonance derived myocardial strain assessment using feature tracking. J Vis Exp. 2011 Feb 12;(48):2356. doi: 10.3791/2356.
  28. Kaluzynski K, Chen X, Emelianov SY, Skovoroda AR, O’Donnell M. Strain rate imaging using two-dimensional speckle tracking. IEEE Trans Ultrason Ferroelectr Freq Control. 2001;48:1111–23
  29. Modesto KM, Cauduro S, Dispenzieri A, Khandheria B, Belohlavek M, Lysyansky P, Friedman Z, Gertz M, Abraham TP.Two-dimensional acoustic pattern derived strain parameters closely correlate with one-dimensional tissue Doppler derived strain measurements. Eur J Echocardiogr. 2006 Aug;7(4):315-21.
  30. Sarvari SI, Haugaa KH, Zahid W, Bendz B, Aakhus S, Aaberge L, Edvardsen T.Layer-specific quantification of myocardial deformation by strain echocardiography may reveal significant CAD in patients with non-ST-segment elevation acute coronary syndrome. JACC Cardiovasc Imaging. 2013 May;6(5):535-44.
  31. Andre F, Steen H, Matheis P, Westkott M, Breuninger K, Sander Y, Kammerer R, Galuschky C, Giannitsis E, Korosoglou G, Katus HA, Buss SJ.Age- and gender-related normal left ventricular deformation assessed by cardiovascular magnetic resonance feature tracking. J Cardiovasc Magn Reson. 2015 Mar 10;17(1):25. doi: 10.1186/s12968-015-0123-3.
  32. St John Sutton MG, Reichek N, Kastor JA, et al. Computerized M-mode echocardiographic analysis of left ventricular dysfunction in cardiac amyloid. Circulation 1982;66:790–9.
  33. Ganau A, Saba PS, Roman MJ, et al. Ageing induces left ventricular concentric remodelling in normotensive subjects. J Hypertens 1995;13:1818–22.
  34. Gerstenblith G, Frederiksen J, Yin FC, et al. Echocardiographic assessment of a normal adult aging population. Circulation 1977;56:273–8.
  35. Knutsen KM, Stugaard M, Michelsen S, et al. M-mode echocardiographic findings in apparently healthy, non-athletic Norwegians aged 20-70 years. Influence of age, sex and body surface area. J Intern Med 1989;225:111–5.
  36. Pandian NG, Skorton DJ, Collins SM, et al. Heterogeneity of left ventricular segmental wall thickening and excursion in 2-Dimensional echocardiograms of normal human subjects. Am J Cardiol 1983;51:1667–73.
  37. Lima JAC, Jeremy R, Guier W, et al. Accurate systolic wall thickening by nuclear magnetic resonance imaging with tissue tagging: correlation with sonomicrometers in normal and ischemic myocardium. J Am Coll Cardiol 1993;21:1741–51.
  38. Sun JP, Lee AP-W, Wu C, et al. Quantification of left ventricular regional myocardial function using two-dimensional speckle tracking echocardiography in healthy volunteers-a multi-center study. Int J Cardiol 2013;167:495–501.
  39. Sugimoto T, Dulgheru R, Bernard A, et al. Echocardiographic reference ranges for normal left ventricular 2D strain: results from the EACVI NORRE study. Eur Heart J Cardiovasc Imaging 2017;18:833–40.
  40. Yingchoncharoen T, Agarwal S, Popović ZB, et al. Normal ranges of left ventricular strain: a meta-analysis. J Am Soc Echocardiogr 2013;26:185–91.
  41. Kaku K, Takeuchi M, Tsang W, et al. Age-Related normal range of left ventricular strain and torsion using three-dimensional speckletracking echocardiography. J Am Soc Echocardiogr 2014;27:55–64.
  42. Adamu U, Schmitz F, Becker M, Kelm M, Hoffmann R. Advanced speckle tracking echocardiography allowing a three-myocardial layer-specific analysis of deformation parameters.Eur J Echocardiogr. 2009 Mar;10(2):303-8.
  43. Shimizu G, Hirota Y, Kita Y, Kawamura K, Saito T, Gaasch WH.Left ventricular midwall mechanics in systemic arterial hypertension. Myocardial function is depressed in pressure-overload hypertrophy.
    Circulation. 1991 May;83(5):1676-84. doi: 10.1161/01.cir.83.5.1676.
  44. Sabbah HN, Marzilli M, Stein PD: The relative role of subendocardium and subepicardium in left ventricular mechanics. Am J Physiol 1981;240(6):H920-6. doi: 10.1152/ajpheart.1981.240.6.H920)
  45. Clark NR, Reichek N, Bergey P, Hoffman EA, Brownson D, Palmon L, Axel L. Circumferential myocardial shortening in the normal human left ventricle. Assessment by magnetic resonance imaging using spatial modulation of magnetization. Circulation. 1991 Jul;84(1):67-74. doi: 10.1161/01.cir.84.1.67.
  46. Greenbaum RA, Ho SY, Gibson DG, Becker AE, Anderson RH. Left ventricular fibre architecture in man. Br Heart J. 1981 Mar;45(3):248-63
  47. Voigt JU, Arnold MF, Karlsson M, Hubbert L, Kukulski T, Hatle L, Sutherland GR.Assessment of regional longitudinal myocardial strain rate derived from Doppler myocardial imaging indexes in normal and infarcted myocardium.J Am Soc Echocardiogr. 2000 Jun;13(6):588-98.
  48. Stoylen A, Slordahl S, Skjelvan GK, Heimdal A, Skjaerpe T. Strain Rate Imaging in Normal and Reduced Diastolic Function: Comparison with Pulsed Doppler Tissue Imaging of the Mitral Annulus. J Am Soc Echocardiogr 2001, 14:264-274.
  49. Kowalski M, Kukulski T, Jamal F, D'hooge J, Weidemann F, Rademakers F, Bijnens B, Hatle L, Sutherland GR. Can natural strain and strain rate quantify regional myocardial deformation? A study in healthy subjects. Ultrasound Med Biol. 2001 Aug;27(8):1087-97.
  50. Storaa C, Lind B, Brodin LA. Distribution of left ventricular longitudinal peak systolic strain and impact of low frame rate. Ultrasound Med Biol. 2004 Aug;30(8):1049-55.
  51. Storaa C, Aberg P, Lind B, Brodin LA. Effect of angular error on tissue Doppler velocities and strain. Echocardiography. 2003 Oct;20(7):581-7
  52. Marwick TH, Leano RL, Brown J, Sun JP, Hoffmann R, Lysyansky P, Becker M, Thomas JD. Myocardial strain measurement with 2-dimensional speckle-tracking echocardiography: definition of normal range.JACC Cardiovasc Imaging. 2009 Jan;2(1):80-4. (
  53. Appleton CP.Hemodynamic determinants of Doppler pulmonary venous flow velocity components: new insights from studies in lightly sedated normal dogs.J Am Coll Cardiol. 1997 Nov 15;30(6):1562-74. doi: 10.1016/s0735-1097(97)00354-9.
  54. Carstensen HG, Larsen LH, Hassager C, Kofoed KF, Jensen JS, Mogelvang R.Basal longitudinal strain predicts future aortic valve replacement in asymptomatic patients with aortic stenosis. Eur Heart J Cardiovasc Imaging. 2016 Mar;17(3):283-92.
  55. Lo Q, Haluska B, Chia EM, Lin MW, Richards D, Marwick T, Thomas L. Alterations in regional myocardial deformation assessed by strain imaging in cardiac amyloidosis. Echocardiography. 2016 Dec;33(12):1844-1853.
  56. Bogaert J, Rademakers FE. Regional nonuniformity of normal adult human left ventricle. Am J Physiol Heart Circ Physiol 2001; 280: H610-H620.
  57. Moore CC1, Lugo-Olivieri CH, McVeigh ER, Zerhouni EA.Three-dimensional systolic strain patterns in the normal human left ventricle: characterization with tagged MR imaging.Radiology. 2000 Feb;214(2):453-66
  58. Liu B, Dardeer AM, Moody WE, Hayer MK, Baig S, Price AM, Leyva F, Edwards NC, Steeds RP.Reference ranges for three-dimensional feature tracking cardiac magnetic resonance: comparison with two-dimensional methodology and relevance of age and gender. Int J Cardiovasc Imaging. 2018 May;34(5):761-775. doi: 10.1007/s10554-017-1277-x.
  59. Keren G, Sherez J, Megidish R, Levitt B and Laniado S. Pulmonary venous flow pattern--its relationship to cardiac dynamics. A pulsed Doppler echocardiographic study. Circulation (1985); 71: 1105-1112.
  60. Appleton CP, Hatle LK and Popp RL. Superior vena cava and hepatic vein Doppler echocardiography in healthy adults. Journal of the American College of Cardiology (1987); 10: 1032-1039.
  61. Rossvoll O and Hatle LK. Pulmonary venous flow velocities recorded by transthoracic Doppler ultrasound: relation to left ventricular diastolic pressures. Journal of the American College of Cardiology (1993); 21: 1687-1696.
  62. Carlsson M, Cain P, Holmqvist C, Stahlberg F, Lundback S and Arheden H. Total heart volume variation throughout the cardiac cycle in humans. American journal of physiology Heart and circulatory physiology (2004); 287: H243-250.
  63. Bowman AW and Kovács SJ. Left atrial conduit volume is generated by deviation from the constant-volume state of the left heart: a combined MRI-echocardiographic study. American journal of physiology Heart and circulatory physiology (2004); 286: H2416-2424.
  64. Emilsson K, Brudin L and Wandt B. The mode of left ventricular pumping: is there an outer contour change in addition to the atrioventricular plane displacement? Clinical physiology (Oxford, England) (2001); 21: 437-446.
  65. Støylen A, Dalen H, Molmen HE.Left ventricular longitudinal shortening: relation to stroke volume and ejection fraction in ageing, blood pressure, body size and gender in the HUNT3 study.
    Open Heart. 2020 Sep;7(2):e001243. doi: 10.1136/openhrt-2020-001243
  66. Carlsson M, Ugander M, Mosén H, Buhre T, Arheden H.Atrioventricular plane displacement is the major contributor to left ventricular pumping in healthy adults, athletes, and patients with dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1452-9.
  67. Carlsson M, Ugander M, Heiberg E, Arheden H.The quantitative relationship between longitudinal and radial function in left, right, and total heart pumping in humans. Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H636-44. doi: 10.1152/ajpheart.01376.2006. Epub 2007 Feb 16.
  68. Stephensen S, Steding-Ehrenborg K, Munkhammar P, Heiberg E, Arheden H and Carlsson M. The relationship between longitudinal, lateral, and septal contribution to stroke volume in patients with pulmonary regurgitation and healthy volunteers. American journal of physiology Heart and circulatory physiology (2014); 306: H895-903.
  69. Margulescu AD, Rees E, Coulson RM, Rees AD, Vinereanu D, Fraser AG.Do left atrial strain and strain rate reflect intrinsic atrial function, or are they determined by left ventricular function? Kardiol Pol. 2015;73(7):539-48. doi: 10.5603/KP.a2015.0035.
  70. Mălăescu GG, Mirea O, Capotă R, Petrescu AM, Duchenne J, Voigt JU. Left Atrial Strain Determinants During the Cardiac Phases. JACC Cardiovasc Imaging. 2022 Mar;15(3):381-391. doi: 10.1016/j.jcmg.2021.09.009.
  71. Badano LP, Kolias TJ, Muraru D, Abraham TP, Aurigemma G, Edvardsen T, D'Hooge J, Donal E, Fraser AG, Marwick T, Mertens L, Popescu BA, Sengupta PP, Lancellotti P, Thomas JD and Voigt JU. Standardization of left atrial, right ventricular, and right atrial deformation imaging using two-dimensional speckle tracking echocardiography: a consensus document of the EACVI/ASE/Industry Task Force to standardize deformation imaging. European heart journal cardiovascular Imaging (2018); 19: 591-600.
  72. Støylen A, Daae AS.Physiological significance of pre- and post-ejection left ventricular tissue velocities and relations to mitral and aortic valve closures. Clin Physiol Funct Imaging. 2021 Sep;41(5):443-451. doi: 10.1111/cpf.12721.
  73. Cassidy DM, Vassallo JA, Marchlinski FE, Buxton AE, Untereker WJ, Josephson ME. Endocardial mapping in humans in sinus rhythm with normal left ventricles: activation patterns and characteristics of electrograms.Circulation. 1984 Jul;70(1):37-42.
  74. Rademakers FE, Buchalter MB, Rogers WJ, Zerhouni EA, Weisfeldt ML, Weiss JL, Shapiro EP. Dissociation between left ventricular untwisting and filling. Accentuation by catecholamines. Circulation 1992;85:1572–1581
  75. Takeuchi M, Nakai H, Kokumai M, Nishikage T, Otani S, Lang RM. Age-related changes in left ventricular twist assessed by twodimensional speckle-tracking imaging. J Am Soc Echocardiogr 2006;19:1077–1084.
  76. Sasson Z, Hatle L, Appleton CP, Jewett M, Alderman EL, Popp RL.Intraventricular flow during isovolumic relaxation: description and characterization by Doppler echocardiography. J Am Coll Cardiol. 1987 Sep;10(3):539-46.
  77. Stoylen A, Slordahl S, Skjelvan GK, Heimdal A, Skjaerpe T. Strain Rate Imaging in Normal and Reduced Diastolic Function: Comparison with Pulsed Doppler Tissue Imaging of the Mitral Annulus. J Am Soc Echocardiogr 2001, 14:264-274.
  78. Sonnenblick, EH. Force-velocity relations in mammalian heart muscle. Am. J. Physiol. 1962. 202 (5) : 931-939.
  79. Bonow RO, Mann DL, Zipes DP, Libby P. Braunwald's, heart disease, A Textbook of Cardiovascular Medicine, 9th ed. 2012, Elsevier Saunders, ISBN 978-1-4377-0398-6, p 477-82
  80. Kraigher-Krainer E, Shah AM, Gupta DK, et al. Impaired systolic function by strain imaging in heart failure with preserved ejection fraction. J Am Coll Cardiol 2014;63:447–56.
  81. Mizuguchi Y, Oishi Y, Miyoshi H, et al. Concentric left ventricular hypertrophy brings deterioration of systolic longitudinal, circumferential, and radial myocardial deformation in hypertensive patients with preserved left ventricular pump function. J Cardiol 2010;55:23–33.
  82. Serri K, Reant P, Lafitte M, et al. Global and regional myocardial function quantification by two-dimensional strain: application in hypertrophic cardiomyopathy. J Am Coll Cardiol 2006;47:1175–81.
  83. SW Patterson, EH Starling. On the mechanical factors which determine the output of the ventricles.  The Journal of physiology, 1914.
  84. Sagawa K, Suga H, Shoukas AA, Bakalar KM. End-systolic pressure/volume ratio: a new index of ventricular contractility. Am J Cardiol. 1977 Nov;40(5):748-53.
  85. Spratt JA, Tyson GS, Glower DD, Davis JW, Muhlbaier LH, Olsen CO, Rankin JS. The end-systolic pressure-volume relationship in conscious dogs. Circulation. 1987 Jun;75(6):1295-309.
  86. Burkhoff D, Sugiura S, Yue DT, Sagawa K. Contractility-dependent curvilinearity of end-systolic pressure-volume relations. Am J Physiol. 1987 Jun;252(6 Pt 2):H1218-27.
  87. Glower DD, Spratt JA, Snow ND, Kabas JS, Davis JW, Olsen CO, Tyson GS, Sabiston DC Jr, Rankin JS. Linearity of the Frank-Starling relationship in the intact heart: the concept of preload recruitable stroke work. Circulation. 1985 May;71(5):994-1009.
  88. van der Velde ET, Burkhoff D, Steendijk P, Karsdon J, Sagawa K, Baan J. Nonlinearity and load sensitivity of end-systolic pressure-volume relation of canine left ventricle in vivo. Circulation. 1991 Jan;83(1):315-27.
  89. Suga H.Total mechanical energy of a ventricle model and cardiac oxygen consumption. Am J Physiol. 1979 Mar;236(3):H498-505.
  90. Takaoka H1, Takeuchi M, Odake M, Yokoyama M.Assessment of myocardial oxygen consumption (Vo2) and systolic pressure-volume area (PVA) in human hearts.Eur Heart J. 1992 Nov;13 Suppl E:85-90.
  91. SONNENBLICK EH, DOWNING SE.Afterload as a primary determinat of ventricular performance.Am J Physiol. 1963 Apr;204:604-10.
  92. Ingul CB, Stoylen A, Slordahl SA.  Recovery of stunned myocardium in acute myocardial infarction quantified by strain rate imaging: a clinical study. J Am Soc Echocardiogr. 2005 May;18(5):401-10.  
  93. Stoylen A, Skjaerpe T. Systolic long axis function of the left ventricle. Global and regional information. Scand Cardiovasc J. 2003 Sep;37(5):253-8.
  94. Pahlm U, Seemann F, Engblom H, Gyllenhammar T, Halvorsen S, Hansen HS, Erlinge D, Atar D, Heiberg E, Arheden H, Carlsson M. Longitudinal left ventricular function is globally depressed within a week of STEMI. Clin Physiol Funct Imaging. 2018 Apr 27.
  95. Höglund C, Alam M, Thorstrand C. Effects of acute myocardial infarction on the displacement of the atrioventricular plane: an echocardiographic study. J Intern Med 1989 Oct;226(4):251-6
  96. Zhang Y, Chan AK, Yu CM, Yip GW, Fung JW, Lam WW, So NM, Wang M, Wu EB, Wong JT, Sanderson JE., et al. Strain rate imaging differentiates transmural from non-transmural myocardial infarction a validation study using delayed-enhancement magnetic resonance imaging. J AmColl Cardiol 2005;46:864 –71.
  97. Gjesdal O, Hopp E, Vartdal T, Lunde K, Helle-Valle T, Aakhus S, Smith HJ, Ihlen H, Edvardsen T. Global longitudinal strain measured by two-dimensional speckle tracking echocardiography is closely related to myocardial infarct size in chronic ischaemic heart disease.Clin Sci (Lond). 2007 Sep;113(6):287-96.
  98. Mondillo S, Galderisi M, Ballo P, Marino PN; Study Group of Echocardiography of the Italian Society of Cardiology. Left ventricular systolic longitudinal function: comparison among simple M-mode, pulsed, and M-mode color tissue Doppler of mitral annulus in healthy individuals. J Am Soc Echocardiogr. 2006 Sep;19(9):1085-91.
  99. Thorstensen A, Dalen H, Amundsen BH, Aase SA, Stoylen A. Reproducibility in echocardiographic assessment of the left ventricular global and regional function, the HUNT study.  Eur J Echocardiogr. 2010 Mar;11(2):149-56.
  100. RUSHMER RF, CRYSTAL DK, WAGNER C.The functional anatomy of ventricular contraction. Circ Res. 1953 Mar;1(2):162-70. doi: 10.1161/01.res.1.2.162.
  101. Carlsson M, Ugander M, Mosen H, Buhre T and Arheden H. Atrioventricular plane displacement is the major contributor to left ventricular pumping in healthy adults, athletes, and patients with dilated cardiomyopathy. American journal of physiology Heart and circulatory physiology (2007); 292: H1452-1459.
  102. Marcus Carlsson, Martin Ugander, Einar Heiberg, and Hakan Arheden. The quantitative relationship between longitudinal and radial function in left, right, and total heart pumping in humans.Am J Physiol Heart Circ Physiol 293: H636–H644, 2007.
  103. Støylen, Asbjørn; Dalen, Håvard; Mølmen Hansen, Harald. Normal values for TAPSE in the HUNT study of subjects without evidence of heart disease. Euroecho; 2019-12-04 - 2019-12-07 NTNU
  104. SPENCER MP, GREISS FC. Dynamics of ventricular ejection. Circ Res. 1962 Mar;10:274-9.
  105. REEVES TJ, et al. The hemodynamic determinants of the rate of change in pressure in the left ventricle during isometric contraction. Am Heart J. 1960. PMID: 13740337
  106. WALLACE AG, SKINNER NS Jr, MITCHELL JH. Hemodynamic determinants of the maximal rate of rise of left ventricular pressure. Am J Physiol. 1963 Jul;205:30-6.
  107. Mason DT, Braunwald E, Covell JW, Sonnenblick EH, Ross J Jr. Assessment of cardiac contractility. The relation between the rate of pressure rise and ventricular pressure during isovolumic systole. Circulation. 1971 Jul;44(1):47-58.
  108. Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, Pannier B, Vlachopoulos C, Wilkinson I, Struijker-Boudier H; European Network for Non-invasive Investigation of Large Arteries. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006 Nov;27(21):2588-605.
  109. Weidemann F, Jamal F, Sutherland GR, Claus P, Kowalski M, Hatle L, De Scheerder I, Bijnens B, Rademakers FE. Myocardial function defined by strain rate and strain during alterations in inotropic states and heart rate. Am J Physiol Heart Circ Physiol. 2002 Aug;283(2):H792-9.
  110. Weissler AM, Harris WS, Schoenfeld CD. Systolic time intervals in heart failure in man.Circulation. 1968 Feb;37(2):149-59.
  111. Durrer D, van Dam RT, Freud GE, Janse MJ, Meijler FL, Arzbaecher RC.Total excitation of the isolated human heart.Circulation. 1970 Jun;41(6):899-912.
  112. Endocardial mapping in humans in sinus rhythm with normal left ventricles: activation patterns and characteristics of electrograms.Circulation. 1984 Jul;70(1):37-42. Cassidy DM, Vassallo JA, Marchlinski FE, Buxton AE, Untereker WJ, Josephson ME.
  113. Cordeiro JM, Greene L, Heilmann C, Antzelevitch D, Antzelevitch C. Transmural heterogeneity of calcium activity and mechanical function in the canine left ventricle.Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1471-9.
  114. Brekke B, Nilsen LC, Lund J, Torp H, Bjastad T, Amundsen BH, Stoylen A, Aase SA. Ultra-high Frame Rate Tissue Doppler Imaging.Ultrasound Med Biol. 2014 Jan;40(1):222-31.
  115. Laniado S, Yellin EL, Miller H, Frater RW. Temporal relation of the first heart sound to closure of the mitral valve. Circulation. 1973 May;47(5):1006-14.
  116. Tsakiris AG, Gordon DA, Padiyar R, Fréchette D. Relation of mitral valve opening and closure to left atrial and ventricular pressures in the intact dog.Am J Physiol. 1978 Feb;234(2):H146-51.
  117. Remme EW, Lyseggen E, Helle-Valle T, Opdahl A, Pettersen E, Vartdal T, Ragnarsson A, Ljosland M, Ihlen H, Edvardsen T, Smiseth OA. Mechanisms of preejection and postejection velocity spikes in left ventricular myocardium: interaction between wall deformation and valve events.Circulation. 2008 Jul 22;118(4):373-80.
  118. Annichen Søyland DaaeAS, Wigen MS, Fadnes S, Løvstakken L, Støylen A. Intraventricular Vector Flow Imaging with Blood Speckle Tracking in Adults: Feasibility, Normal Physiology and Mechanisms in Healthy Volunteers, Ultrasound in Medicine & Biology, 2021, https://doi.org/10.1016/j.ultrasmedbio.2021.08.021.
  119. Li Q, Huang L, Ma N, Li Z, Han Y, Wu L, Zhang X, Li Y, Zhang H. Relationship between left ventricular vortex and preejectional flow velocity during isovolumic contraction studied by using vector flow mapping. Echocardiography 2019;36:558–566.
  120. Sherrid MV, Kushner J, Yang G, Ro R. Mitral valve coaptation and its relationship to late diastolic flow: A color Doppler and vector flow map echocardiographic study in normal subjects. Echocardiography 2017;34:537–548.
  121. Mason DT, Braunwald E, Covell JW, Sonnenblick EH, Ross J Jr. Assessment of cardiac contractility. The relation between the rate of pressure rise and ventricular pressure during isovolumic systole. Circulation. 1971 Jul;44(1):47-58.
  122. Bargiggia GS, Bertucci C, Recusani F, Raisaro A, de Servi S, Valdes-Cruz LM, Sahn DJ, Tronconi L. A new method for estimating left ventricular dP/dt by continuous wave Doppler-echocardiography. Validation studies at cardiac catheterization. Circulation. 1989 Nov;80(5):1287-92.
  123. Gulati VK, Katz WE, Follansbee WP, Gorcsan J 3rd. Mitral annular descent velocity by tissue Doppler echocardiography as an index of global left ventricular function. Am J Cardiol 1996 May 1;77(11):979-84
  124. Vinereanu D, Ionescu AA, Fraser AG.  Assessment of left ventricular long axis contraction can detect early myocardial dysfunction in asymptomatic patients with severe aortic regurgitation. Heart. 2001 Jan;85(1):30-6.
  125. Vinereanu D, Florescu N, Sculthorpe N, Tweddel AC, Stephens MR, Fraser AG. Differentiation between pathologic and physiologic left ventricular hypertrophy by tissue Doppler assessment of long-axis function in patients with hypertrophic cardiomyopathy or systemic hypertension and in athletes. Am J Cardiol. 2001 Jul 1;88(1):53-8.
  126. Stoylen A, Skjaerpe T. Systolic long axis function of the left ventricle. Global and regional information. Scand Cardiovasc J. 2003 Sep;37(5):253-8.
  127. Weidemann F, Jamal F, Sutherland GR, Claus P, Kowalski M, Hatle L, De Scheerder I, Bijnens B, Rademakers FE. Myocardial function defined by strain rate and strain during alterations in inotropic states and heart rate. Am J Physiol Heart Circ Physiol. 2002 Aug;283(2):H792-9.
  128. Weidemann F, Jamal F, Kowalski M, Kukulski T, D'Hooge J, Bijnens B, Hatle L, De Scheerder I, Sutherland GR. Can strain rate and strain quantify changes in regional systolic function during dobutamine infusion, B-blockade, and atrial pacing--implications for quantitative stress echocardiography. J Am Soc Echocardiogr. 2002 May;15(5):416-24.
  129. Greenberg NL, Firstenberg MS, Castro PL, Main M, Travaglini A, Odabashian JA, Drinko JK, Rodriguez LL, Thomas JD, Garcia MJ. Doppler-derived myocardial systolic strain rate is a strong index of left ventricular contractility. Circulation. 2002 Jan 1;105(1):99-105.
  130. Thorstensen A, Dalen H, Amundsen BH, Støylen A.Peak systolic velocity indices are more sensitive than end-systolic indices in detecting contraction changes assessed by echocardiography in young healthy humans. Eur J Echocardiogr. 2011 Dec;12(12):924-30.
  131. Muntwyler J, Abetel G, Gruner C, Follath F. One-year mortality among unselected outpatients with heart failure.Eur Heart J. 2002 Dec;23(23):1861-6.
  132. Yip G, Wang M, Zhang Y, Fung JW, Ho PY, Sanderson JE. Left ventricular long axis function in diastolic heart failure is reduced in both diastole and systole: time for a redefinition?Heart. 2002 Feb;87(2):121-5.
  133. Höglund C, Alam M, Shorthand C. Atrioventricular valve plane displacement in healthy persons. An echocardiographic study. Acta med. Scand 1988;224(6):557-62
  134. Simonson JS, Schiller NB. Descent of the base of the left ventricle: an echocardiographic index of left ventricular function. J Am Soc Echocardiogr 1989;2:25-35
  135. Jones CJ, Raposo L, Gibson DG. Functional importance of the long axis dynamics of the human left ventricle. Br Heart J 1990;63:215-20
  136. Alam M, Höglund C, Thorstrand C, Philip A. Atrioventricular plane displacement in severe congestive heart failure following dilated cardiomyopathy or myocardial infarction. J Intern Med 1990 Dec;228(6):596-75
  137. Carlhall CJ, Lindstrom L, Wranne B, Nylander E. Atrioventricular plane displacement correlates closely to circulatory dimensions but not to ejection fraction in normal young subjects. Clin Physiol. 2001 Sep;21(5):621-8.
  138. Wandt B, Bojö L, Tolagen K, Wranne B. Echocardiographic assessment of ejection fraction in left ventricular hypertrophy. Heart. 1999 Aug;82(2):192-8.
  139. Vinereanu D, Nicolaides E, Tweddel AC, Fraser AG. "Pure" diastolic dysfunction is associated with long-axis systolic dysfunction. Implications for the diagnosis and classification of heart failure. Eur J Heart Fail. 2005 Aug;7(5):820-8.
  140. Willenheimer R, Cline C, Erhardt L, Israelsson B. Left ventricular atrioventricular plane displacement: an echocardiographic technique for rapid assessment of prognosis in heart failure. Heart 1997;78:230-36.
  141. Sveälv BG, Olofsson EL, Andersson B. Ventricular long-axis function is of major importance for long-term survival in patients with heart failure. Heart. 2008 Mar;94(3):284-9.
  142. Ballo P, Barone D, Bocelli A, Motto A, Mondillo S. Left ventricular longitudinal systolic dysfunction is an independent marker of cardiovascular risk in patients with hypertension.Am J Hypertens. 2008 Sep;21(9):1047-54.
  143. Elnoamany MF, Abdelhameed AK. Mitral annular motion as a surrogate for left ventricular function: correlation with brain natriuretic peptide levels.Eur J Echocardiogr. 2006 Jun;7(3):187-98.
  144. Brutsaert DL and Sys SU. Relaxation and diastole of the heart. PHYSIOLOGICAL REVIEWS Vol. 69, No. 4, October 1989
  145. Sasson Z, Hatle L, Appleton CP, Jewett M, Alderman EL, Popp RL.Intraventricular flow during isovolumic relaxation: description and characterization by Doppler echocardiography. J Am Coll Cardiol. 1987 Sep;10(3):539-46.
  146. Stoylen A, Slordahl S, Skjelvan GK, Heimdal A, Skjaerpe T. Strain Rate Imaging in Normal and Reduced Diastolic Function: Comparison with Pulsed Doppler Tissue Imaging of the Mitral Annulus. J Am Soc Echocardiogr 2001, 14:264-274.
  147. CJ Wiggers. Studies on the consecutive phases of the cardiac cycle  American Journal of Physiology--Legacy …, 1921 - Am Physiological Soc
  148. Abel FL.Maximal negative dP/dt as an indicator of end of systole.Am J Physiol. 1981 Apr;240(4):H676-9.
  149. Stig A. Slørdahl, Steinar Bjærum, Brage H. Amundsen, Asbjørn Støylen, Andreas Heimdal, Stein Inge Rabben,  Hans Torp. High frame rate strain rate imaging of the ventricular septum in healthy subjects. Eur J Ultrasound 2001 Dec;14(2-3):149-55.
  150. Aase SA, Stoylen A, Ingul CB, Frigstad S, Torp H. Automatic timing of aortic valve closure in apical tissue Doppler images. Ultrasound Med Biol. 2006 Jan;32(1):19-27.
  151. Aase SA, Torp H, Støylen A. Aortic valve closure: relation to tissue velocities by Doppler and speckle tracking in normal subjects. Eur J Echocardiogr. 2008 Jul;9(4):555-9.
  152. Aase SA, Björk-Ingul C, Thorstensen A, Torp H, Støylen A. Aortic valve closure: relation to tissue velocities by Doppler and speckle tracking in patients with infarction and at high heart rates.  Echocardiography. 2010 Apr;27(4):363-9.
  153. Aase SA, Bjåstad T, Brekke B Støylen A. Novel high frame rate sparse tissue Doppler imaging. Poster Euroecho 2010, Copenhagen 08 - 11 Dec 2010. P657. In:   Eur J Echocardiogr  (2010)   11  (suppl 2):  ii86-ii88.   doi: 10.1093/ejechocard/jeq143
  154. Brekke B, Nilsen LC, Lund J, Torp H, Bjastad T, Amundsen BH, Stoylen A, Aase SA. Ultra-high Frame Rate Tissue Doppler Imaging.Ultrasound Med Biol. 2014 Jan;40(1):222-31.
  155. Kanai H. Propagation of spontaneously actuated pulsive vibration in human heart wall and in vivo viscoelasticity estimation. IEEE Trans Ultrason Ferroelectr Freq Control 2005;52:1931–1942.
  156. Støylen A, Mølmen HE, Dalen H.Regional motion of the AV-plane is related to the cardiac anatomy and deformation of the AV-plane. Data from the HUNT study. Clin Physiol Funct Imaging. 2023 Jul 3. doi: 10.1111/cpf.12845.
  157. Appleton CP. Hemodynamic determinants of Doppler pulmonary venous flow velocity components: new insights from studies in lightly sedated normal dogs. J Am Coll Cardiol. 1997 Nov 15;30(6):1562-74.
  158. Appleton CP, Hatle LK, Popp RL. Relation of transmitral flow velocity patterns to left ventricular diastolic function: new insights from a combined hemodynamic and Doppler echocardiographic study. J Am Coll Cardiol. 1988 Aug;12(2):426-40.
  159. Brun P, Triboully C, Duval A-M, Iserin L, Meguira A, Pelle G, Dubois-Rande JL.: Left ventricular flow propagation during early filling is related to wall relaxation: A colour M-mode analysis. J Am Coll Cardiol 1992, 20:420-432.
  160. Stugaard M, Steen T, Lundervold A, et al.: Visual assessment of intra ventricular flow from colour M-mode Doppler images. Int J Cardiac Imaging 1994, 10:279-289
  161. Garcia MJ, Smedira NG, Greenberg NL, Main M, Firstenberg MS, Odabashian J, Thomas JD.: Color M-mode Doppler flow propagation is a preload insensitive index of left ventricular relaxation: animal and human validation. J Am Coll Cardiol 2000, 35:201-208.
  162. Farias CA, Rodriguez L, Garcia MJ, Sun JP, Klein AL, Thomas JD. Assessment of diastolic function by tissue Doppler echocardiography: comparison with standard transmitral and pulmonary venous flow. J Am Soc Echocardiogr. 1999 Aug;12(8):609-17.
  163. Støylen A, Skjelvan G, Skjaerpe T. Flow propagation velocity is not a simple index of diastolic function in early filling. A comparative study of early diastolic strain rate and strain rate propagation, flow and flow propagation in normal and reduced diastolic function. Cardiovasc Ultrasound. 2003, 1:3
  164. Pai RG, Shakudo M, Yoganathan AP, Shah PM.Clinical correlates of the rate of transmission of transmitral "A" wave to the left ventricular outflow tract in left ventricular hypertrophy secondary to systemic hypertension, hypertrophic cardiomyopathy or aortic valve stenosis. Am J Cardiol. 1994 Apr 15;73(11):831-4.
  165. Stoylen A, Slordahl S, Skjelvan GK, Heimdal A, Skjaerpe T. Strain Rate Imaging in Normal and Reduced Diastolic Function: Comparison with Pulsed Doppler Tissue Imaging of the Mitral Annulus. J Am Soc Echocardiogr 2001, 14:264-274.
  166. Steen T, Steen S: Filling of a model left ventricle studied by colour M mode Doppler. Cardiovascular research 1994, 28:1821-1827.
  167. Rodevand O, Bjornerheim R, Edvardsen T, Smiseth OA, Ihlen H. Diastolic flow pattern in the normal left ventricle. J Am Soc Echocardiogr. 1999 Jun;12(6):500-7.
  168. Nagueh SF, Middleton KJ, Kopelen HA, Zoghbi WA, Quinones MA. Doppler tissue imaging: a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures. J Am Coll Cardiol. 1997 Nov 15;30(6):1527-33.
  169. Farias CA, Rodriguez L, Garcia MJ, Sun JP, Klein AL, Thomas JD. Assessment of diastolic function by tissue Doppler echocardiography: comparison with standard transmitral and pulmonary venous flow. J Am Soc Echocardiogr. 1999 Aug;12(8):609-17.
  170. Ommen SR, Nishimura RA, Appleton CP, Miller FA, Oh JK, Redfield MM et al. Clinical utility of Doppler echocardiography and tissue Doppler imaging in the estimation of left ventricular filling pressures: a comparative simultaneous Doppler-catheterization study. Circulation 2000; 102:1788–94.
  171. Rustad LA, Amundsen BH, Slørdahl SA, Støylen A. Upright bicycle exercise echocardiography in patients with myocardial infarction shows lack of diastolic, but not systolic, reserve: a tissue Doppler study.Eur J Echocardiogr. 2009 Jun;10(4):503-8.
  172. Mullens W, Borowski AG, Curtin RJ, Thomas JD, Tang WH. Tissue Doppler imaging in the estimation of intracardiac filling pressure in decompensated patients with advanced systolic heart failure. Circulation 2009;119:62-70.
  173. Garcia MJ, Rodriguez L, Ares M, Griffin BP, Thomas JD, Klein AL. Differentiation of constrictive pericarditis from restrictive cardiomyopathy: assessment of left ventricular diastolic velocities in longitudinal axis by Doppler tissue imaging. J Am Coll Cardiol 1996;27:108-14.
  174. Maksuti E, Carlsson M, Arheden H, Kovács SJ, Broomé M and Ugander M. Hydraulic forces contribute to left ventricular diastolic filling. Sci Rep (2017); 7: 43505.
  175. R A Nishimura  1 , M D Abel, L K Hatle, A J TajikRelation of pulmonary vein to mitral flow velocities by transesophageal Doppler echocardiography. Effect of different loading conditionsCirculation . 1990 May;81(5):1488-97. 
  176. Kuecherer HF, Muhiudeen IA, Kusumoto FM, Lee E, Moulinier LE, Cahalan MK, Schiller NB. Estimation of mean left atrial pressure from transesophageal pulsed Doppler echocardiography of pulmonary venous flow. Circulation. 1990 Oct;82(4):1127-39.
  177. Tennant R, Wiggers Cl. The effect of coronary occlusion on myocardial contraction. Am 1 Physiol 1935;112:351-61.
  178. Henry PD, Schuchleib R, Davis J, Weiss ES, Sobel BE. Myocardial contracture and accumulation of mitochondrial calcium in ischemic rabbit heart. American Journal of Physiology - Heart and Circulatory Physiology Published 1 December 1977 Vol. 233 no. 6, H677-H684
  179. Brutsaert DL, Rademakers FE, Sys SU. Triple control of relaxation: implications in cardiac disease. Circulation. 1984 Jan;69(1):190-6.
  180. Brutsaert DL, Rademakers FE, Sys SU, Gillebert TC, Housmans PR. The heart as an integrated muscle and pump system: triple control and subdivision of the cardiac cycle.Brutsaert DL, Rademakers FE, Sys SU, Gillebert TC, Housmans PR.Acta Cardiol. 1984;39(2):89-95.
  181. Lyseggen E1, Skulstad H, Helle-Valle T, Vartdal T, Urheim S, Rabben SI, Opdahl A, Ihlen H, Smiseth OA. Myocardial strain analysis in acute coronary occlusion: a tool to assess myocardial viability and reperfusion. Circulation. 2005 Dec 20;112(25):3901-10.
  182. Ingul CB, Stoylen A, Slordahl SA.  Recovery of stunned myocardium in acute myocardial infarction quantified by strain rate imaging: a clinical study. J Am Soc Echocardiogr. 2005 May;18(5):401-10.
  183. Ingul CB, Malm S, Refsdal E, Hegbom K, Amundsen BH, Støylen A.Recovery of function after acute myocardial infarction evaluated by tissue Doppler strain and strain rate. J Am Soc Echocardiogr. 2010 Apr;23(4):432-8.
  184. Pahlm U, Seemann F, Engblom H, Gyllenhammar T, Halvorsen S, Hansen HS, Erlinge D, Atar D, Heiberg E, Arheden H, Carlsson M. Longitudinal left ventricular function is globally depressed within a week of STEMI. Clin Physiol Funct Imaging. 2018 Apr 27.
  185. Höglund C, Alam M, Thorstrand C. Effects of acute myocardial infarction on the displacement of the atrioventricular plane: an echocardiographic study. J Intern Med 1989 Oct;226(4):251-6
  186. Zhang Y, Chan AK, Yu CM, Yip GW, Fung JW, Lam WW, So NM, Wang M, Wu EB, Wong JT, Sanderson JE., et al. Strain rate imaging differentiates transmural from non-transmural myocardial infarction a validation study using delayed-enhancement magnetic resonance imaging. J AmColl Cardiol 2005;46:864 –71.
  187. Gjesdal O, Hopp E, Vartdal T, Lunde K, Helle-Valle T, Aakhus S, Smith HJ, Ihlen H, Edvardsen T. Global longitudinal strain measured by two-dimensional speckle tracking echocardiography is closely related to myocardial infarct size in chronic ischaemic heart disease.Clin Sci (Lond). 2007 Sep;113(6):287-96.
  188. Hisano R, Cooper G 4th.Correlation of force-length area with oxygen consumption in ferret papillary muscle. Circ Res. 1987 Sep;61(3):318-28.
  189. Tyberg JV, Forrester JS, Wyatt HL, Goldner SJ, Parmley WW, Swan HJ.An analysis of segmental ischemic dysfunction utilizing the pressure-length loop.Circulation. 1974 Apr;49(4):748-54.
  190. Forrester JS, Tyberg JV, Wyatt HL, Goldner S, Parmely WW, Swan HJ.Pressure-length loop: a new method for simultaneous measurement of segmental and total cardiac function.J Appl Physiol. 1974 Nov;37(5):771-5.
  191. Delhaas T, Arts T, Prinzen FW, Reneman RS.Regional fibre stress-fibre strain area as an estimate of regional blood flow and oxygen demand in the canine heart.  J Physiol. 1994 Jun 15;477 ( Pt 3):481-96.
  192. Glower DD, Spratt JA, Snow ND, Kabas JS, Davis JW, Olsen CO, Tyson GS, Sabiston DC Jr, Rankin JS. Linearity of the Frank-Starling relationship in the intact heart: the concept of preload recruitable stroke work. Circulation. 1985 May;71(5):994-1009.
  193. Urheim S, Rabben SI, Skulstad H, Lyseggen E, Ihlen H, Smiseth OA.Regional myocardial work by strain Doppler echocardiography and LV pressure: a new method for quantifying myocardial function. Am J Physiol Heart Circ Physiol. 2005 May;288(5):H2375-80. doi: 10.1152/ajpheart.00946.2004.
  194. Russell K, Eriksen M, Aaberge L, Wilhelmsen N, Skulstad H, Remme EW, Haugaa KH, Opdahl A, Fjeld JG, Gjesdal O, Edvardsen T, Smiseth OA. A novel clinical method for quantification of regional left ventricular pressure-strain loop area: a non-invasive index of myocardial work. Eur Heart J. 2012 Mar;33(6):724-33. doi: 10.1093/eurheartj/ehs016. PMID: 22315346
  195. Heimdal A, Stoylen A, Torp H, Skjaerpe T. Real-time strain rate imaging of the left ventricle by ultrasound. J Am Soc Echocardiogr 1998 Nov;11(11):1013-19
  196. Stoylen A, Heimdal A, Bjornstad K, Torp H, Skjaerpe T. Strain rate imaging by ultrasound in the diagnosis of regional dysfunction of the left ventricle. Echocardiography 1999 May; 16(4):321-9
  197. Stoylen A, Heimdal A Bjornstad K, Wiseth R, Vik-Mo H, Torp H, Angelsen B, Skjærpe T. Strain rate imaging by ultrasound in the diagnosis of coronary artery disease. J Am Soc Echocardiogr 2000 Dec;13(12):1053-64
  198. Henein MY, O'Sullivan C, Davies SW, Sigwart U, Gibson DG. Effects of acute coronary occlusion and previous ischaemic injury on left ventricular wall motion in humans. Heart. 1997 Apr;77(4):338-45.
  199. Kukulski T, Jamal F, D'Hooge J, Bijnens B, De Scheerder I, Sutherland GR. Acute changes in systolic and diastolic events during clinical coronary angioplasty: a comparison of regional velocity, strain rate, and strain measurement. J Am Soc Echocardiogr. 2002 Jan;15(1):1-12.
  200. Kukulski T, Jamal F, Herbots L, D'hooge J, Bijnens B, Hatle L, De Scheerder I, Sutherland GR.  Identification of acutely ischemic myocardium using ultrasonic strain measurements. A clinical study in patients undergoing coronary angioplasty. J Am Coll Cardiol. 2003 Mar 5;41(5):810-9.
  201. Lyseggen E1, Skulstad H, Helle-Valle T, Vartdal T, Urheim S, Rabben SI, Opdahl A, Ihlen H, Smiseth OA. Myocardial strain analysis in acute coronary occlusion: a tool to assess myocardial viability and reperfusion. Circulation. 2005 Dec 20;112(25):3901-10.
  202. Braunwald E, Kloner RA. The stunned myocardium: prolonged, postischemic ventricular dysfunction. Circulation. 1982; 66: 1146-1149
  203. Weidemann F,Wacker C, Rauch A, Bauer WR, Bijnens B, Sutherland GR, et al. Sequential changes of myocardial function during acute myocardial infarction, in the early and chronic phase after coronary intervention described by ultrasonic strain rate imaging. J Am Soc Echocardiogr 2006; 19:839-47
  204. Voigt JU, Lindenmeier G, Exner B, Regenfus M, Werner D, Reulbach U, Nixdorff U, Flachskampf FA, Daniel WG. Incidence and characteristics of segmental postsystolic longitudinal shortening in normal, acutely ischemic, and scarred myocardium. J Am Soc Echocardiogr. 2003 May;16(5):415-23.
  205. Dillon JC, Chang S, Feigenbaum H. Echocardiographic manifestations of left bundle branch block.Circulation. 1974 May;49(5):876-80.
  206. Parsai C, Bijnens B, Sutherland GR, Baltabaeva A, Claus P, Marciniak M, Paul V, Scheffer M, Donal E, Derumeaux G, Anderson L.Toward understanding response to cardiac resynchronization therapy: left ventricular dyssynchrony is only one of multiple mechanisms. Eur Heart J. 2009 Apr;30(8):940-9.
  207. Voigt JU, Schneider TM, Korder S, Szulik M, Gürel E, Daniel WG, Rademakers F, Flachskampf FA.Apical transverse motion as surrogate parameter to determine regional left ventricular function inhomogeneities: a new, integrative approach to left ventricular asynchrony assessment. Eur Heart J. 2009 Apr;30(8):959-68.
  208. Long-term left ventricular reverse remodelling with cardiac resynchronization therapy: results from the CARE-HF trial. Ghio S, Freemantle N, Scelsi L, Serio A, Magrini G, Pasotti M, Shankar A, Cleland JG, Tavazzi L. Eur J Heart Fail. 2009 May;11(5):480-8.
  209. Cleland JG, Daubert JC, Erdmann E, Freemantle N, Gras D, Kappenberger L, Tavazzi L; Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators.The effect of cardiac resynchronization on morbidity and mortality in heart failure.N Engl J Med. 2005 Apr 14;352(15):1539-49.
  210. Cleland JG, Freemantle N, Erdmann E, Gras D, Kappenberger L, Tavazzi L, Daubert JC. Long-term mortality with cardiac resynchronization therapy in the Cardiac Resynchronization-Heart Failure (CARE-HF) trial. Eur J Heart Fail. 2012 Jun;14(6):628-34. 
  211. Chung ES, Leon AR, Tavazzi L, Sun JP, Nihoyannopoulos P, Merlino J, Abraham WT, Ghio S, Leclercq C, Bax JJ, Yu CM, Gorcsan J 3rd, St John Sutton M, De Sutter J, Murillo J.Results of the Predictors of Response to CRT (PROSPECT) trial. Circulation. 2008 May 20;117(20):2608-16.
  212. Risum N, Jons C, Olsen NT, Fritz-Hansen T, Bruun NE, Hojgaard MV, Valeur N, Kronborg MB, Kisslo J, Sogaard P. Simple regional strain pattern analysis to predict response to cardiac resynchronization therapy: rationale, initial results, and advantages. Am Heart J. 2012 Apr;163(4):697-704.
  213. Mor-Avi V1, Collins KA, Korcarz CE, Shah M, Spencer KT, Lang RM.Detection of regional temporal abnormalities in left ventricular function during acute myocardial ischemia.Am J Physiol Heart Circ Physiol. 2001 Apr;280(4):H1770-81.
  214. Podgoreanu MV, Djaiani GN, Davis E, Phillips-Bute B, Mathew JP. Quantitative echocardiographic assessment of regional wall motion and left ventricular asynchrony with color kinesis in cardiac surgery patients. Anesth Analg. 2003 May;96(5):1294-300,
  215. Marwick TH. Stress echocardiography. Its role in the diagnosis and evaluation of coronary Artery Disease. 2nd ed. Kluwer Academic publishers 2003. ISBN: 1-4020-7369-0
  216. Aase SA, Björk-Ingul C, Thorstensen A, Torp H, Støylen A. Aortic valve closure: relation to tissue velocities by Doppler and speckle tracking in patients with infarction and at high heart rates.  Echocardiography. 2010 Apr;27(4):363-9.
  217. Mechanism of Abnormal Septal Motion in Left Bundle Branch Block: Role of Left Ventricular Wall Interactions and Myocardial Scar.
    Aalen JM, Remme EW, Larsen CK, Andersen OS, Krogh M, Duchenne J, Hopp E, Ross S, Beela AS, Kongsgaard E, Bergsland J, Odland HH, Skulstad H, Opdahl A, Voigt JU, Smiseth OA.
    JACC Cardiovasc Imaging. 2019 Dec;12(12):2402-2413.
  218. Mechanical Effects on Right Ventricular Function From Left Bundle Branch Block and Cardiac Resynchronization Therapy.
    Storsten P, Aalen JM, Boe E, Remme EW, Gjesdal O, Larsen CK, Andersen ØS, Eriksen M, Kongsgaard E, Duchenne J, Voigt JU, Smiseth OA, Skulstad H.
    JACC Cardiovasc Imaging. 2020 Jul;13(7):1475-1484.
  219. Angelsen BA. Ultrasound imaging. Waves, signals and signal processing. Trondheim 2000. Emantec, Norway.
  220. Edler I, Hertz CH. The use of ultrasonic reflectoscope for the continuous recording of the movements of heart walls. Kungl Fysiogr Sallsk Lund Forh.. 1954;24:40.
  221. Mondillo, S., Galderisi, M., Ballo, P. & Marino, P.N. (2006) Left ventricular systolic longitudinal function: comparison among simple M‐mode, pulsed, and M‐mode color tissue Doppler of mitral annulus in healthy individuals. Journal of the American Society of Echocardiography, 19, 1085–1091
  222. Ochs, M.M., Fritz, T., André, F., Riffel, J., Mereles, D., Müller‐Hennessen, M. et al. (2017) A comprehensive analysis of cardiac valve plane displacement in healthy adults: age‐stratified normal values by cardiac magnetic resonance. The International Journal of Cardiovascular Imaging, 33, 721–729.
  223. Rudski, L.G., Lai, W.W., Afilalo, J., Hua, L., Handschumacher, M.D., Chandrasekaran, K. et al. (2010) Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. Journal of the American Society of Echocardiography: official publication of the American Society of Echocardiography, 23, 685–713
  224. Lang, R.M., Badano, L.P., Mor‐Avi, V., Afilalo, J., Armstrong, A., Ernande, L. et al. (2015) Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of cardiovascular imaging. Journal of the American Society of Echocardiography, 28, 1–39.
  225. Stoylen A, Wisloff U, Slordahl S.  Left ventricular mechanics during exercise: a Doppler and tissue Doppler study. Eur J Echocardiogr. 2003 Dec;4(4):286-91
  226. Weissler AM, Harris WS, Schoenfeld CD. Systolic time intervals in heart failure in man. Circulation 1967; 37: 149–159.
  227. Bazett HC. An analysis of the time-relations of electrocardiograms. Heart 1920; 7: 353.
  228. Jaeger KM, Rahko PS. Doppler characteristics of late-diastolic flow in the left ventricular outflow tract. J Am Soc Echocardiogr. 1990 May-Jun;3(3):179-86.

  230. Angelsen BA. Ultrasound imaging. Waves, signals and signal processing. Trondheim 2000. Emantec, Norway.
  231. Nykvist H. Certain topics in telegraph transmission theory, Trans. AIEE, vol. 47, pp. 617-644, Apr. 1928
  232. Ihlen H, Amlie JP, Dale J, Forfang K, Nitter-Hauge S, Otterstad JE, Simonsen S, Myhre E. Determination of cardiac output by Doppler echocardiography. Br Heart J. 1984 Jan;51(1):54-60.
  233. Skjaerpe T, Hegrenaes L, Hatle L. Noninvasive estimation of valve area in patients with aortic stenosis by Doppler ultrasound and two-dimensional echocardiography. Circulation. 1985 Oct;72(4):810-8.
  234. Holen J, Aaslid R, Landmark K, Simonsen S. Determination of pressure gradient in mitral stenosis with a non-invasive ultrasound Doppler technique. Acta Med Scand. 1976;199(6):455-60.
  235. Hatle L, Brubakk A, Tromsdal A, Angelsen B. Noninvasive assessment of pressure drop in mitral stenosis by Doppler ultrasound. Br Heart J. 1978 Feb;40(2):131-40.
  236. Hatle L, Angelsen BA, Tromsdal A. Non-invasive assessment of aortic stenosis by Doppler ultrasound. Br Heart J. 1980 Mar;43(3):284-92.
  237. Skjaerpe T, Hatle L. Noninvasive estimation of systolic pressure in the right ventricle in patients with tricuspid regurgitation. Eur Heart J. 1986 Aug;7(8):704-10.
  238. Isaaz K, Thompson A, Ethevenot G, Cloez JL, Brembilla B, Pernot C. Doppler echocardiographic measurement of low velocity motion of the left ventricular posterior wall. Am J Cardiol. 1989 Jul 1;64(1):66-75.
  239. McDicken WN, Sutherland GR, Moran CM, Gordon LN. Colour Doppler velocity imaging of the myocardium. Ultrasound Med Biol. 1992;18(6-7):651-4.
  240. Aase, Svein Arne; Torp, Hans; Amundsen, Brage H.; Bjåstad, Tore; Støylen, Asbjørn. Peak sysotlic velocity by upper edge of pulsed wave tissue Doppler spectrums cause overestimation compared to M-mode in normal subjects. Euroecho 2008, Lyon, 10-13 dec. European Journal of Echocardiography 2008 ;Volum 9. Suppl. 1 s. S7-S8
  241. Manouras A, Shahgaldi K, Winter R, Nowak J, Brodin LA. Comparison between colour-coded and spectral tissue Doppler measurements of systolic and diastolic myocardial velocities: effect of temporal filtering and offline gain setting.Eur J Echocardiogr. 2009 May;10(3):406-13.
  242. Manouras A, Shala A, Nyktari E, Shahgaldi K, Winter R, Vardas P, Brodin LA, Nowak J. Are measurements of systolic myocardial velocities and displacement with colour and spectral Tissue Doppler compatible? Cardiovasc Ultrasound. 2009 Jun 23;7:29. doi: 10.1186/1476-7120-7-29.
  243. Brekke B, Nilsen LC, Lund J, Torp H, Bjastad T, Amundsen BH, Stoylen A, Aase SA. Ultra-high Frame Rate Tissue Doppler Imaging.Ultrasound Med Biol. 2014 Jan;40(1):222-31.
  244. Schiller NB, Shah PM, Crawford M, DeMaria A, Devereux R, Feigenbaum H, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr 1989;2:358e67.
  245. Echocardiographic Reference Ranges of Global Longitudinal Strain for All Cardiac Chambers Using Guideline-Directed Dedicated Views. Nyberg J, Jakobsen EO, Østvik A, Holte E, Stølen S, Lovstakken L, Grenne B, Dalen H. JACC: Cardiovascular Imaging Available online 1 November 2023
  246. Bohs LN, Trahey GE. A novel method for angle independent ultrasonic imaging of blood flow and tissue motion. IEEE Trans Biomed Eng. 1991 Mar;38(3):280-6.
  247. Insana MF, Wagner RF, Garra BS, Momenan R, Shawker TH. Pattern recognition methods for optimizing multivariate tissue signatures in diagnostic ultrasound. Ultrason Imaging. 1986 Jul;8(3):165-80.
  248. Kanai H, Satoh H, Hirose K, Chubachi N. A new method for measuring small local vibrations in the heart using ultrasound. IEEE Trans Biomed Eng. 1993 Dec;40(12):1233-42
  249. Eriksen-Volnes T, Grue JF, Hellum Olaisen S, Letnes JM, Nes B, Løvstakken L, Wisløff U, Dalen H. Normalized Echocardiographic Values From Guideline-Directed Dedicated Views for Cardiac Dimensions and Left Ventricular Function. JACC Cardiovasc Imaging. 2023 Jan 14:S1936-878X(22)00751-3. doi: 10.1016/j.jcmg.2022.12.020.
  250. Kou S, Caballero L, Dulgheru R, Voilliot D, De Sousa C, Kacharava G, Athanassopoulos GD, Barone D, Baroni M, Cardim N, Gomez De Diego JJ, Hagendorff A, Henri C, Hristova K, Lopez T, Magne J, De La Morena G, Popescu BA, Penicka M, Ozyigit T, Rodrigo Carbonero JD, Salustri A, Van De Veire N, Von Bardeleben RS, Vinereanu D, Voigt JU, Zamorano JL, Donal E, Lang RM, Badano LP, Lancellotti P.Echocardiographic reference ranges for normal cardiac chamber size: results from the NORRE study. Eur Heart J Cardiovasc Imaging. 2014 Jun;15(6):680-90.
  251. Sepúlveda-Martínez A, Steding-Ehrenborg K, Rodríguez-López M, Ostenfeld E, Valenzuela-Alcaráz B, Heiberg E, Gratacós E, Prat-González S, Crispi F, Hedström E. Atrioventricular plane displacement versus mitral and tricuspid annular plane systolic excursion: A comparison between cardiac magnetic resonance and M-mode echocardiography. Clin Physiol Funct Imaging. 2021 May;41(3):262-270.
  252. Henry WL, Gardin JM, Ware JH. Echocardiographic measurements in normal subjects from infancy to old age. Circulation 1980;62:1054–61.
  253. Devereux RB, Lutas EM, Casale PN, et al. Standardization of M-mode echocardiographic left ventricular anatomic measurements. J Am Coll Cardiol 1984;4:1222–30.
  254. Brodin LA, van der Linden J, Olstad B. Echocardiographic functional images based on tissue velocity information. Herz 1998, 23:1183-1199.
  255. Nathan H, Eliakim M.The junction between the left atrium and the pulmonary veins. An anatomic study of human hearts. Circulation. 1966 Sep;34(3):412-22.
  256. Ho SY, Cabrera JA, Tran VH, Farré J, Anderson RH, Sánchez-Quintana D.Architecture of the pulmonary veins: relevance to radiofrequency ablation. Heart. 2001 Sep;86(3):265-70.
  257. Bowman AW, Kovács SJ.Prediction and assessment of the time-varying effective pulmonary vein area via cardiac MRI and Doppler echocardiography. Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H280-6.
  258. Choi SI, Seo JB, Choi SH, Lee SH, Do KH, Ko SM, Lee JS, Song JW, Song KS, Choi KJ, Kim YH, Lim TH.Variation of the size of pulmonary venous ostia during the cardiac cycle: optimal reconstruction window at ECG-gated multi-detector row CT. Eur Radiol. 2005 Jul;15(7):1441-5.
  259. Thiagalingam A, Reddy VY, Cury RC, Abbara S, Holmvang G, Thangaroopan M, Ruskin JN, d'Avila A.Pulmonary vein contraction: characterization of dynamic changes in pulmonary vein morphology using multiphase multislice computed tomography scanning. Heart Rhythm. 2008 Dec;5(12):1645-50.
  260. Sunagawa K, Maughan WL, Burkhoff D, Sagawa K.Left ventricular interaction with arterial load studied in isolated canine ventricle. Am J Physiol. 1983 Nov;245(5 Pt 1):H773-80.
  261. Sunagawa K, Maughan WL, Sagawa K.Optimal arterial resistance for the maximal stroke work studied in isolated canine left ventricle. Circ Res. 1985 Apr;56(4):586-95.
  262. Kelly RP, Ting C-T, Yang T-Met al,Effective Arterial Elastance as Index of Arterial Vascular Load in Humans. Circulation 1992;86:513-521
  263. Hammermeister KE, et al. The rate of change of left ventricular volume in man. I. Validation and peak systolic ejection rate in health and disease. Circulation. 1974. PMID: 4856332
  264. F Van de Werf, J Minten, P Carmeliet, H De Geest, H Kesteloot The genesis of the third and fourth heart sounds. A pressure flow study in dogs.J Clin Invest . 1984 May;73(5):1400-7.
  265. Dodge HT, Sandler H, Baxley WA, Hawley RR.Usefulness and limitations of radiographic methods for determining left ventricular volume. Am J Cardiol. 1966 Jul;18(1):10-24.
  266. Hammermeister KE, Brooks RC, Warbasse JR.The rate of change of left ventricular volume in man. I. Validation and peak systolic ejection rate in health and disease. Circulation. 1974 Apr;49(4):729-38.
  267. MARK I. M. NOBLE,  DIANA TRENCHARD and  ABRAHAM GUZLeft Ventricular Ejection in Conscious Dogs: I. Measurement and Significance of the Maximum Acceleration of Blood from the Left Ventricle Circulation Research. 1966;19:139–147
  268. MARK I. M. NOBLE The Contribution of Blood Momentum to Left Ventricular Ejection in the Dog Circulation Research. 1968;23:663–670
  269. Courtois M, Kovács SJ Jr, Ludbrook PA.Transmitral pressure-flow velocity relation. Importance of regional pressure gradients in the left ventricle during diastole. Circulation. 1988 Sep;78(3):661-71.
  270. Carmeliet P, Aubert A, Van de Werf F, De Geest H.Evaluation of transmitral pressure gradients at different heart rates: divergent action of isoprenaline and atropine. Cardiovasc Res. 1990 Jul;24(7):560-9.
  271. Thorstensen A, Dalen H, Hala P, Kiss G, D'hooge J, Torp H, Støylen A, Amundsen B. Three-dimensional echocardiography in the evaluation of global and regional function in patients with recent myocardial infarction: a comparison with magnetic resonance imaging. Echocardiography. 2013 Jul;30(6):682-92.
  272. Angelsen BA. Ultrasound imaging. Waves, signals and signal processing. Trondheim 2000. Emantec, Norway.
  273. Thorstensen A, Amundsen BH, Dalen H, Hala P, Kiss G, Aase SA, Torp H, Støylen A. Strain rate imaging combined with wall motion analysis gives incremental value in direct quantification of myocardial infarct size.Eur Heart J Cardiovasc Imaging. 2012 Nov;13(11):914-21.
  274. Bjaerum S, Torp H, Kristoffersen K. High frame rate tissue Doppler imaging. Vol. 2. New York, IEEE, 2001:1417–1421
  275. Lind B, Nowak J, Dorph J, van der Linden J, Brodin LA. Analysis of temporal requirements for myocardial tissue velocity imaging. Eur J Echocardiogr. 2002 Sep;3(3):214-9.
  276. Gunnes S, Storaa C, Lind B, Nowak J, Brodin LA.Analysis of the effect of temporal filtering in myocardial tissue velocity imaging.J Am Soc Echocardiogr. 2004 Nov;17(11):1138-45.
  277. Storaa C, Lind B, Brodin LA. Distribution of left ventricular longitudinal peak systolic strain and impact of low frame rate. Ultrasound Med Biol. 2004 Aug;30(8):1049-55.
  278. Brekke, Birger; Aase, Svein Arne; Torp, Hans; Bjåstad, Tore; Støylen, Asbjørn. 3D Tissue Doppler imaging with ultra high frame rate. EEE International Ultrasonics Symposium 2011; 2011-10-18 - 2011-10-21EEE International Ultrasonics Symposium Proceedings 2012
  279. Lichtenstein D, Meziere G, Biderman P, Gepner A, Barre O. The comet-tail artifact. An ultrasound sign of alveolar-interstitial syndrome. Am J Respir Crit Care Med 1997;156:1640–1646
  280. Lichtenstein D, Meziere G. A lung ultrasound sign allowing bedside distinction between pulmonary edema and chronic obstructive pulmonary disease: the comet-tail artifact. Intensive Care Med 1998;24:1331–1334.
  281. Jambrik Z, Monti S, Coppola V, Agricola E, Mottola G, Miniati M, Picano E. Usefulness of ultrasound lung comets as a nonradiologic sign of extravascular lung water.Am J Cardiol. 2004 May 15;93(10):1265-70.